Marina Elena Emborg

Replicable generation of rhesus macaque iPSCs for in vitro modeling of genetic frontotemporal dementia

This paper describes a reproducible method to generate rhesus macaque induced pluripotent stem cells (RhiPSCs) from MAPT R406W carriers for in vitro modeling of frontotemporal dementia.

Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques

This study measures blood biomarkers of neurodegeneration and inflammation in rhesus macaques across adulthood, finding age-related increases in NfL and IL-6 and a decline in Aβ42/Aβ40 ratio.

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.