PRMT5 activity sustains histone production to maintain genome integrity
Jacob S. Roth, Joseph D. DeAngelo, Dejauwne L. Young, Maxim I. Maron, Ankita Saha, Hugo Borges Pinto, Varun Gupta, Noah Jacobs, Subray S. Hegde, Jennifer T. Aguilan, Joel Basken, Joey Azofeifa, Charles C. Query, Simone Sidoli, Arthur I. Skoultchi, David Shechter
This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.
bioRxiv · Jul 3, 2025 · PreprintCell Biology