K. Leigh Greathouse

Clinical isolates of Fusobacterium nucleatum display strain-specific virulence and modulation by indole derivatives

This study identifies strain-specific virulence in Fusobacterium nucleatum and shows indole derivatives reduce invasion and alter junction transcripts in CRC cells.

Targeted therapy of oncomicrobe F. nucleatum with bioengineered probiotic expressing guided antimicrobial peptide (gAMP)

This paper develops a bioengineered probiotic expressing guided antimicrobial peptides to selectively target Fusobacterium nucleatum in colorectal cancer, showing reduced toxicity to non-target bacteria and preserved gut microbiota diversity.

Outer membrane vesicles from Bacteroides fragilis contain coding and non-coding small RNA species that modulate inflammatory signaling in intestinal epithelial cells.

This study identifies coding and non-coding small RNAs in Bacteroides fragilis outer membrane vesicles that modulate inflammatory responses in intestinal epithelial cells, with ETBF OMVs showing immunosuppressive effects.

Microbiome-TP53 Gene Interaction in Human Lung Cancer

This study identifies a microbiome-TP53 interaction in squamous cell lung cancer, showing Acidovorax enrichment in smokers with TP53 mutations.