Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons
Zhuo Li, Navjot Kaur, Gabriel Santpere, Sydney Keaton Muchnik, Suvimal Kumar Sindhu, Cai Qi, Mikihito Shibata, Olivier Clément, Thomas Klarić, Xabier de Martin, Victor A Luria, Hyesun Cho, Mingfeng Li, Akemi Shibata, Andrew T.N. Tebbenkamp, , Nenad Šestan
The paper identifies mammalian-specific gene regulatory elements and their role in neocortical neuron subtype diversity and connectivity, linking them to neurodevelopmental disorders.
bioRxiv · May 20, 2025 · PreprintNeuroscience