Author

Mariana Garcia Sanchez

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Brian CoventryiD· 2 shared David A. BakeriD· 2 shared Inna GoreshnikiD· 2 shared Adeleye Oluwatosin AdeshakiniD· 1 shared Aditya KrishnakumariD· 1 shared Alex KangiD· 1 shared Andrew N. Nemecek· 1 shared Anthony A. HighiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Brian CoventryORCID

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2 papers

Recent·Most cited

Reprogramming CAR T-Cells with designed bioPROTACs

Vivek S. Peche, Sebastian Kenny, Tae Gun Kang, Brian Coventry, Tian Mi, Inna Goreshnik, Mariana Garcia Sanchez, Reid Martin, Macey Smith, Dionne K. Vafeados, Rahul S. Kathayat, Kaiwen Yu, Zuo-Fei Yuan, Long Wu, Anthony A. High, , Stephen M Gottschalk

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

bioRxiv · Feb 22, 2026 · PreprintImmunology

Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists

Matthias Glögl, Aditya Krishnakumar, Robert J. Ragotte, Inna Goreshnik, Brian Coventry, Asim K. Bera, Alex Kang, Emily Joyce, Green Ahn, Buwei Huang, Wei Yang, Wei Chen, Mariana Garcia Sanchez, Brian Koepnick, David A. Baker

This study uses target-conditioned diffusion to design high-affinity TNFR superfamily antagonists and agonists with switchable specificity.

Science · Dec 5, 2024Peer-reviewedBiochemistry