Juan I. Bravo

Acute LINE-1 overexpression rewires the transcriptome, proteome and secretome of primary human fibroblasts

This study shows that acute LINE-1 overexpression in human fibroblasts causes widespread changes in transcriptome, proteome, and secretome, affecting cell cycle and interferon pathways, beyond retrotransposition.

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

This study shows that overexpressing an Alu transposon in human fibroblasts causes widespread disruptions in aging-related pathways across transcriptome, proteome, and secretome.

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers

This study uses a multi-ancestry GWAS to identify genetic loci associated with variation in LINE-1 and Alu insertion numbers, highlighting potential regulatory mechanisms and disease links.

An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells

The paper identifies candidate regulators of LINE-1 RNA levels in lymphoblastoid cells using eQTL analysis and validates some candidates experimentally.

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

The paper presents a multi-omic analysis of mouse neutrophils, identifying age and sex-related differences in chromatin regulation and predicting increased neutrophil elastase release in males.

Remodeling of the H3 nucleosomal landscape during mouse aging

The paper analyzes H3 nucleosome occupancy changes in aging mouse tissues and neural stem cells, finding local chromatin accessibility shifts linked to pro-inflammatory gene expression.