Samah Shah

This study shows that oral DBM treatment prevents cognitive decline in a C9ORF72 FTD mouse model without altering protein inclusions but corrects gene expression changes related to cytoskeleton, ALS, and metabolism.

This study shows that overexpressing an Alu transposon in human fibroblasts causes widespread disruptions in aging-related pathways across transcriptome, proteome, and secretome.

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

This study shows that a short-term cyclic ketogenic diet improves memory and synaptic plasticity in aged mice by modulating the cAMP/PKA signaling pathway and cytoskeleton dynamics.

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.