Ryan J. Lu

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

This study identifies sex-specific aging-related changes in mouse peritoneal macrophages, driven by both hormone-dependent and -independent mechanisms.

This study systematically compares three mouse menopause models to identify shared and model-specific features of follicle loss and endocrine disruption using single-cell transcriptomics and machine learning.

The paper identifies sex-dimorphic gene expression patterns in mouse macrophages across niches, finding three consistently differentially expressed genes and female-biased pathways related to extracellular matrix components.

This paper provides a transcriptional dataset of aging tissues from African turquoise killifish, showing age has a greater impact than sex on gene expression and TE transcription.

Directly-reprogrammed human neurons show reduced neurite growth ability with age, mirroring rodent developmental patterns.

This study shows that KOMP Fshr heterozygous knockout mice do not exhibit accelerated ovarian aging phenotypes previously reported in another Fshr haploinsufficiency model.

The paper identifies that NHR-8 regulates P-glycoproteins in C. elegans, uncoupling xenobiotic stress resistance from longevity in osm-3 mutants.

The paper presents a multi-omic analysis of mouse neutrophils, identifying age and sex-related differences in chromatin regulation and predicting increased neutrophil elastase release in males.