Minhoo Kim

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

This study creates a multi-omic atlas of brain aging in African turquoise killifish, identifying glucocorticoid signaling activation as a key feature of aging and showing its inhibition can reverse aging phenotypes.

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain

This study uses a Drosophila model to show that RNA exosome mutations disrupt brain transcriptomes and cause neurodegeneration by altering rRNA processing.

Single-cell exploration of ovarian aging across mammalian models

This study analyzes ovarian aging across species using single-cell RNA-seq data to identify conserved and species-specific features and suggests drug repurposing candidates.

Mouse peritoneal macrophages undergo female-specific remodeling with aging driven by both hormone-dependent and -independent mechanisms

This study identifies sex-specific aging-related changes in mouse peritoneal macrophages, driven by both hormone-dependent and -independent mechanisms.

Systematic characterization of the ovarian landscape across mouse menopause models

This study systematically compares three mouse menopause models to identify shared and model-specific features of follicle loss and endocrine disruption using single-cell transcriptomics and machine learning.

Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.

Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model

This study shows that KOMP Fshr heterozygous knockout mice do not exhibit accelerated ovarian aging phenotypes previously reported in another Fshr haploinsufficiency model.

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

The paper presents a multi-omic analysis of mouse neutrophils, identifying age and sex-related differences in chromatin regulation and predicting increased neutrophil elastase release in males.