Sophie Layé

Dietary fructose promotes anxiety through impairment of microglia physiology

This study shows that dietary fructose causes anxiety by impairing microglia function, with sex-specific effects on metabolism and behavior.

Standardized brain and plasma EV enrichment pipeline validated for Single sample multi-Omic and fatty acids applications in Mouse and Human

The paper presents a standardized workflow for multi-omic profiling of brain and plasma-derived EVs from minimal human and mouse material, revealing tissue-specific and species-specific molecular signatures.

Fructose malabsorption induces dysbiosis and increases anxiety in Human and animal models

This paper investigates how fructose malabsorption affects gut microbiota and neuroinflammation, linking these changes to anxiety in humans and mice.

Maternal n-3 PUFA deficiency alters brain fatty acid and oxylipin profiles across perinatal development in offspring

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

This study identifies altered blood metabolites in severe AUD patients and links them to psychological symptoms, suggesting new therapeutic targets.

Microglial adipose triglyceride lipase regulates neuroinflammatory and behavioural responses to LPS

This study shows that inhibiting ATGL in microglia reduces LPS-induced inflammation and sickness behavior in mice.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.