Author

Nithya Balasundaram

de Duve InstituteORCID 0000-0002-0004-9483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Fleur Leguay· 2 shared Nick van GasteliD· 2 shared Aby AbrahamiD· 1 shared Andrew A. LaneiD· 1 shared Anu KorulaiD· 1 shared Arvind VenkatramaniD· 1 shared Ayşegül Erdem· 1 shared Azeem ShardaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Fleur Leguay

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells

Nithya Balasundaram, Ayşegül Erdem, Azeem Sharda, Veerle W. Daniëls, Phillip L. Chea, Fleur Leguay, YOUZHONG LIU, Mark A. Keibler, Charles Vidoudez, Andrew A. Lane, Didier Vertommen, Hans Casteur, Michaël R. Laurent, Sunia A. Trauger, Gregory N Stephanopoulos, , Nick van Gastel

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

bioRxiv · Mar 3, 2026 · PreprintCancer Biology

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy

Hernán A. Tirado, Nithya Balasundaram, Jean Jacobs, Fleur Leguay, Lotfi Laaouimir, Nick van Gastel

This study investigates the role of EAAT1 in AML cell growth and therapy response, finding that EAAT1 inhibition does not impair AML growth or chemosensitivity.

PLoS ONE · Feb 24, 2026Peer-reviewedCancer Biology

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

Nithya Balasundaram, Arvind Venkatraman, Yolanda Sydney Augustin, Hamenth Kumar Palani, Clément Regnault, Anu Korula, Uday Prakash Kulkarni, Eunice Sindhuvi Edison, Poonkuzhali Balasubramanian, Biju George, Aby Abraham, Sanjeev Krishna, Vikram Mathews

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

bioRxiv · Jun 23, 2024 · PreprintCancer Biology