Àlex Bayés

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

This study investigates genotype-phenotype correlations in SYNGAP1 Encephalopathy, finding that variant location and type, along with modifier genes, influence clinical severity and autistic traits.

The paper characterizes synaptic proteome diversity in hippocampal trisynaptic circuits and identifies differential expression of glutamate receptor regulatory proteins.

SynaptopathyDB integrates synapse proteomic and genetic data to identify synaptic gene variants associated with neurological and systemic disorders.

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

The paper identifies sublayer- and cell-type-specific transcriptional changes in hippocampal sclerosis using single-nucleus and bulk RNA sequencing, revealing distinct neurodegenerative trajectories in superficial CA1 neurons.

The paper investigates SynGAP splice variants' spatio-temporal expression and subcellular distribution in the developing mammalian brain, finding isoform-specific patterns and localization changes.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.