Marie Doumic

Telomere dynamics parameters inferred from mathematical modeling of telomere length distribution

The paper develops a mathematical model to infer telomere dynamics parameters from telomere length distributions in yeast using long-read sequencing data.

Acute Smurf mortality and age-dependence in a two-phase ageing model: Statistical inference from drosophila and mice experimental data

The paper develops a two-phase ageing model using Drosophila and mouse data, showing a sharp transition to frailty with high early mortality and age-dependent mortality rates.

Both Genome Instability and Replicative Senescence Stem from the Shortest Telomere in Telomerase-Negative Cells

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

Deciphering the Replication-Division Coordination in E. coli: A Unified Mathematical framework for Systematic Model Comparison

This paper develops a unified mathematical framework to compare models of DNA replication and cell division coordination in E. coli, finding that a double-process model better explains experimental data across growth conditions.

Individual cell fate and population dynamics revealed by a mathematical model linking telomere length and replicative senescence

This study develops a mathematical model to link telomere length and replicative senescence in yeast, revealing population dynamics and factors affecting proliferation capacity.

Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae

The paper models non-terminal cell cycle arrests in telomerase-negative yeast to show they arise from a generation-dependent process distinct from terminal senescence.