Jeff S. Mumm

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

A zebrafish phenotypic drug screen identifies 49 ApoB-lowering compounds, with enoxolone showing efficacy dependent on HNF4 function, validating the LipoGlo platform for B-lp modulation.

Mechanochemical cues control the coupling of metabolic and migratory patterns in cancer

The paper shows that cancer cells switch between glycolysis and oxidative phosphorylation based on microenvironment stiffness, affecting their migration patterns.

Threshold-Free Neural Network Models for Swim Bout Detection of Larval Zebrafish

This paper develops threshold-free deep learning models for detecting swim bouts in larval zebrafish, showing improved precision over traditional methods and revealing behavioral patterns across genetic backgrounds.

Optimized chemogenetic ablation and regeneration of enteric nervous system neurons in zebrafish

This study develops a chemogenetic ablation model in zebrafish to study ENS neuron regeneration, showing complete restoration of most neuron subtypes but partial recovery of serotonergic neurons.

Fluorescently-labeled split-QF hemidrivers: simplifying and enhancing methods enabling intersectional targeting of discrete cell types

The paper develops fluorescently labeled split-QF and QF2 hemidrivers in zebrafish to simplify intersectional targeting and enable quality control of split-driver function.

Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

Versatile high-speed volumetric imaging from microscopic to macroscopic scale by self-adaptive oblique plane microscopy

This paper introduces a self-adaptive oblique plane microscopy technique that enables high-speed volumetric imaging across microscopic to macroscopic scales in multi-cellular systems.

Developing a zebrafish xenograft model of diffuse midline glioma

This paper develops a zebrafish xenograft model for diffuse midline glioma by transplanting human DMG cells into zebrafish embryos to enable high-throughput drug screening.

Molecular regulation of retinal regeneration is context specific

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses

The paper compares transcriptomic responses in zebrafish following rod photoreceptor or bipolar cell loss, identifying cell-specific and shared regenerative gene programs and immune-related regulators.

Thalamic neurons drive distinct forms of motor asymmetry that are conserved in teleost and dependent on visual evolution

The paper shows motor asymmetry in larval teleosts is conserved across species and driven by thalamic neurons, with forms dependent on vision and independent of it.

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.

Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration in the zebrafish retina

This study shows that dendrimer-targeted immunosuppression of microglia accelerates photoreceptor regeneration in zebrafish retinas.