Rosalba Lepore

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates β-thalassemia model

This paper demonstrates a method using CD117-blocking antibody and epitope-engineered HSPCs to treat β-thalassemia without myeloablative conditioning.

Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific Immunotherapy

This study identifies natural genetic variants in human therapeutic target antigens that can disrupt antibody binding, leading to resistance to antibody-based therapies.

Patient stratification reveals the molecular basis of disease comorbidities

The paper develops a method to generate a disease network using RNA-seq data, revealing molecular mechanisms behind comorbidities and identifying new associations through patient stratification.

Unraveling the molecular basis of host cell receptor usage in SARS-CoV-2 and other human pathogenic β-CoVs

This study identifies specificity determining positions in SARS-CoV-2 and other β-CoVs spike proteins that encode host receptor usage through sequence and structural analysis.

Insights on protein thermal stability: a graph representation of molecular interactions

The paper introduces a graph-theoretical framework to assess protein thermal stability using structural data, achieving 76% accuracy in distinguishing thermostable from mesostable proteins.