Lukas T. Jeker

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates β-thalassemia model

This paper demonstrates a method using CD117-blocking antibody and epitope-engineered HSPCs to treat β-thalassemia without myeloablative conditioning.

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific Immunotherapy

This study identifies natural genetic variants in human therapeutic target antigens that can disrupt antibody binding, leading to resistance to antibody-based therapies.

Longitudinal profiling of tumor-reactive T cells during TIL therapy in metastatic melanoma

This study profiles tumor-reactive T cell dynamics during TIL therapy in metastatic melanoma, identifying factors associated with response and resistance.

Tmem127-mediated immune receptor degradation regulates T cell homeostasis through the common gamma chain

The paper identifies Tmem127 as a regulator of T cell homeostasis by controlling IL-7 receptor surface expression and common gamma chain interactions.

Identification of DOK2 and PTPN11 as novel interactors of T cell specific adapter protein TSAd

This study identifies DOK2 and PTPN11 as novel interactors of TSAd using AP-MS, revealing their role in negative T cell signaling.