Author

Hongyu Chen

Broad InstituteORCID 0000-0002-9496-8586Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hongyu Chen4 papers · China University of Geosciences (Beijing)

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Jiahao HuangiD· 3 shared Xiao WangiD· 3 shared Connie Kangni WangiD· 2 shared Haowen ZhouiD· 2 shared Hu ZengiD· 2 shared Jennifer A. LoiD· 2 shared Jingyi ReniD· 2 shared Xin SuiiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Jiahao HuangORCID

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Author profile →

3 papers

Recent·Most cited

Spatially resolved translational dysregulation in Grin2a+/- mouse model of schizophrenia

Mingrui Wu, Jiahao Huang, Sameer Aryal, Zohreh Farsi, Hongyu Chen, Yiming Zhou, Shuchen Luo, Wendy Xueyi Wang, Kevin Bonanno, Margaret Yin, Inès Picard, Borislav Dejanovic, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Xiao Wang

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

bioRxiv · Dec 28, 2025 · PreprintNeuroscience

Spatially Resolved Single-cell Translatomics at Molecular Resolution

Hu Zeng, Jiahao Huang, Jingyi Ren, Connie Kangni Wang, Zefang Tang, Haowen Zhou, Yiming Zhou, Hailing Shi, Abhishek J. Aditham, Xin Sui, Hongyu Chen, Jennifer A. Lo, Xiao Wang

The paper introduces RIBOmap, a 3D in situ method to profile mRNA translation at single-cell and spatial resolutions, revealing translation dependencies on cell cycle and subcellular localization in brain tissue.

Science · Jun 29, 2023Peer-reviewedGenomics

Spatiotemporally resolved transcriptomics reveals subcellular RNA kinetic landscape

Jingyi Ren, Haowen Zhou, Hu Zeng, Connie Kangni Wang, Jiahao Huang, Xiaojie Qiu, Xin Sui, Qiang Li, Xunwei Wu, Zuwan Lin, Jennifer A. Lo, Kamal Maher, Yichun He, Xin Tang, Judson Lam, , Xiao Wang

This paper introduces TEMPOmap, a method to profile subcellular RNA kinetics in single cells, revealing kinetic gene clusters with distinct functional roles.

Nature Methods · Apr 10, 2023Peer-reviewedGenomics