Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry
Daniele Peterle, N. Yan, Elena S. Klimtchuk, Bindu Y. Srinivasu, Vesna Brusic, Derek J. Rhoades, Thomas E. Wales, Olga Gursky, Jeffery W. Kelly, John R. Engen, Gareth J. Morgan
This study identifies small molecules that stabilize diverse amyloidogenic immunoglobulin light chains by reducing conformational dynamics and proteolysis.
Journal of Molecular Biology · Jun 29, 2026Peer-reviewedBiophysics