Author

Vesna Brusic

Harvard UniversityORCID 0000-0002-8447-3520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Haley VarnumiD· 2 shared Jesse S. PlungiD· 2 shared Jessica A. PlanteiD· 2 shared Jonathan AbrahamiD· 2 shared Kenneth S. PlanteiD· 2 shared Scott C. WeaveriD· 2 shared Wanyu LiiD· 2 shared Xiaoyi FaniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Haley VarnumORCID

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Author profile →

3 papers

Recent·Most cited

Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses

Jesse S. Plung, Enzo Mameli, Wanyu Li, Anja C. M. de Bruin, Jessica A. Plante, Xiaoyi Fan, Biswajit Das, Bailey C. Willett, Yanhui Hu, Ellie M. Hajovsky, Haley Varnum, Praju Vikas Anekal, Xiaomei Sun, Kate Thornburg, Vesna Brusic, , Jonathan Abraham

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

bioRxiv · Jul 28, 2026 · PreprintMicrobiology

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry

Daniele Peterle, N. Yan, Elena S. Klimtchuk, Bindu Y. Srinivasu, Vesna Brusic, Derek J. Rhoades, Thomas E. Wales, Olga Gursky, Jeffery W. Kelly, John R. Engen, Gareth J. Morgan

This study identifies small molecules that stabilize diverse amyloidogenic immunoglobulin light chains by reducing conformational dynamics and proteolysis.

Journal of Molecular Biology · Jun 29, 2026Peer-reviewedBiophysics

Molecular basis for shifted receptor recognition by an encephalitic arbovirus

Xiaoyi Fan, Wanyu Li, Jessica Oros, Jessica A. Plante, Brooke M. Mitchell, Jesse S. Plung, Himanish Basu, Sivapratha Nagappan-Chettiar, Joshua M. Boeckers, Laurentia V. Tjang, Colin J. Mann, Vesna Brusic, Tierra K. Buck, Haley Varnum, Pan Yang, , Jonathan Abraham

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

Cell · Apr 6, 2025Peer-reviewedMicrobiology