Author

Patricia Melnyk

InsermORCID 0000-0002-9555-3446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Caroline Evrard· 2 shared Luc BuéeiD· 2 shared Mathilde CoevoetiD· 2 shared Nicolas SergeantiD· 2 shared Valérie VingtdeuxiD· 2 shared Adriana Figueroa GarciaiD· 1 shared Alexandre TRICHIES· 1 shared Bernadette Tasiaux· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Caroline Evrard

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2 papers

Recent·Most cited

APP metabolism is regulated by p97/VCP through an autophagy and endolysosome-dependent mechanism

Adriana Figueroa Garcia, Lisa BRISOIRE, Catherine Baud, Raphaëlle Caillierez, Sabiha Eddarkaoui, Caroline Evrard, Jean‐Michel Saliou, Séverine Bégard, Mathilde Coevoet, Hanane Abouelfarah, Alexandre TRICHIES, Luc Buée, Patricia Melnyk, Valérie Vingtdeux, Raphaëlle Pardossi‐Piquard, , Nicolas Sergeant

This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.

bioRxiv · Feb 4, 2026 · PreprintCell Biology

Contribution of the endosomal-lysosomal and proteasomal systems in Amyloid-β Precursor Protein derived fragments processing

Caroline Evrard, Pascal Kienlen‐Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean‐Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux

This study investigates the roles of endosomal-lysosomal and proteasomal pathways in processing APP-derived fragments, showing distinct degradation mechanisms for full-length APP and overexpressed C99.

Frontiers in Cellular Neuroscience · Nov 22, 2018Peer-reviewedNeuroscience