Author

Raphaëlle Caillierez

InsermORCID 0000-0002-6804-9586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Luc BuéeiD· 3 shared Sabiha EddarkaouiiD· 2 shared Séverine Bégard· 2 shared Aatmika BarveiD· 1 shared Adriana Figueroa GarciaiD· 1 shared Alexandre TRICHIES· 1 shared Caroline Evrard· 1 shared Catherine BaudiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Luc BuéeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer Disease

Sarah Guedjdal, Coline Leghay, Maxime J. Derisbourg, Sabiha Eddarkaoui, Simon Lecerf, Florian Vermon, Raphaëlle Caillierez, Séverine Bégard, Claire Regost, Charlotte Laloux, Paulo J. da Costa, Kévin Carvalho, Giovanni Chiappetta, Yann Verdier, Valérie Buée‐Scherrer, , Malika Hamdane

This study identifies and characterizes a novel N-terminally acetylated Tau variant that accumulates in AD models and patients, exacerbates pathology, and is a potential therapeutic target.

Translational Neurodegeneration · Apr 27, 2026Peer-reviewedNeuroscience

APP metabolism is regulated by p97/VCP through an autophagy and endolysosome-dependent mechanism

Adriana Figueroa Garcia, Lisa BRISOIRE, Catherine Baud, Raphaëlle Caillierez, Sabiha Eddarkaoui, Caroline Evrard, Jean‐Michel Saliou, Séverine Bégard, Mathilde Coevoet, Hanane Abouelfarah, Alexandre TRICHIES, Luc Buée, Patricia Melnyk, Valérie Vingtdeux, Raphaëlle Pardossi‐Piquard, , Nicolas Sergeant

This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.

bioRxiv · Feb 4, 2026 · PreprintCell Biology

Astrocyte and mitochondrial footprints in brain-derived extracellular vesicles predict tau pathology

Jeanne Espourteille, Aatmika Barve, Valentin Zufferey, Élodie Leroux, Romain Perbet, Séverine Bagard, Raphaëlle Caillierez, Claude‐Alain Maurage, Nicolas Toni, Luc Buée, Morvane Colin, Kevin Richetin

The paper identifies distinct proteomic signatures in brain-derived extracellular vesicles from 3R and 4R tauopathies, linking them to disease-specific cellular and molecular changes.

bioRxiv · Jan 9, 2025 · PreprintNeuroscience