Akila Mayeda

This study identifies three splicing regulation patterns mediated by UAP56 and URH49 and their association with mRNA export pathways.

The paper identifies RNPS1 in the PSAP complex as a key factor controlling periodic pre-mRNA splicing during the cell cycle, with its protein levels regulated by the ubiquitin-proteasome pathway.

The paper identifies a splicing mechanism in human short introns involving RBM17 and SAP30BP, showing their interaction promotes splicing through a UHM-ULM binding and recruitment to phosphorylated SF3B1.

The paper identifies SPF45/RBM17 as essential for splicing a subset of human short introns, showing it competes with U2AF65 for binding to SF3B1, while U2AF is not required for this process.

The paper identifies the exon junction complex core as a repressor of cancer-specific mRNA re-splicing, showing that its knockdown mimics cancer-like splicing in normal cells.

The paper identifies mammalian-wide interspersed repeats (MIRs) as facilitators of ciRS-7 circular RNA biosynthesis, revealing a new mechanism for circRNA formation.