Karim Rahimi

This study shows that CRISPR-CasRx with synthetic guide RNAs efficiently and specifically depletes circRNAs with minimal off-target effects on linear RNAs.

The paper investigates the transcriptional regulation and processing of the miR-302/367 host gene, revealing complex regulatory sequences and conserved elements between mouse and human.

The paper identifies mammalian-wide interspersed repeats (MIRs) as facilitators of ciRS-7 circular RNA biosynthesis, revealing a new mechanism for circRNA formation.

The paper generates transgenic mice expressing EGFP under miR-302 promoter control and shows its high expression in blastocysts and early stem cells but low expression in adult tissues.

This study shows miR-216b-5p is down-regulated in breast cancer and inhibits proliferation by targeting HDAC8, with lower miR-216b-5p levels linked to lymph node metastasis and larger tumor size.