Thomas B. Hansen

ciRS-7 and miR7 regulate ischemia induced neuronal death via glutamatergic signaling

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.

Chemically synthesized guide RNAs can direct CRISPR-CasRx cleavage of circRNAs with high efficiency and specificity

This study shows that CRISPR-CasRx with synthetic guide RNAs efficiently and specifically depletes circRNAs with minimal off-target effects on linear RNAs.

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

The paper identifies circRAB3IP as a circRNA that modulates cell proliferation by altering gene expression and mRNA processing through interactions with SF3B1 in a paracrine manner.

Signal and noise in circRNA translation

The paper discusses the challenges of distinguishing circRNA translation signal from noise and outlines experimental guidelines for studying circRNA translation.

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis

This study identifies SFPQ as a key regulator of circRNA biogenesis by maintaining long-intron splicing and preventing aberrant splicing events.

circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

The paper identifies circZNF827 as a repressor of neuronal differentiation by forming a transcription-inhibitory complex with hnRNP-K/L proteins and modulating NGFR expression.

Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-Wide Interspersed Repeats (MIRs)

The paper identifies mammalian-wide interspersed repeats (MIRs) as facilitators of ciRS-7 circular RNA biosynthesis, revealing a new mechanism for circRNA formation.

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

This study uses RNA-seq to compare circRNA expression in lesional and non-lesional psoriasis skin, finding reduced circRNA abundance without clear links to miRNA binding site changes.

The RNA Atlas, a single nucleotide resolution map of the human transcriptome

The paper presents a comprehensive human transcriptome atlas with single-nucleotide resolution, identifying thousands of novel RNA species and regulatory interactions.

Non-coding AUG circRNAs constitute an abundant and conserved subclass of circles

The paper identifies and characterizes AUG circRNAs, showing they are abundant, conserved, and produced without Alu elements, but with no evidence of translation.