Christos Pantelis

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Plasma neurofilament light protein provides evidence of accelerated brain ageing in treatment-resistant schizophrenia

The paper examines if plasma NfL levels correlate with age differently in psychiatric disorders compared to healthy individuals, finding accelerated brain aging in treatment-resistant schizophrenia.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

Normative modeling of brain morphometry in Clinical High-Risk for Psychosis

This study examines brain morphometric deviations in individuals at clinical high-risk for psychosis and finds they largely overlap with healthy variation and are not strongly associated with symptom severity or conversion to psychosis.

Affinity Scores: An Individual-centric Fingerprinting Framework for Neuropsychiatric Disorders

The paper introduces a framework to identify individual-specific biopsychosocial fingerprints for neuropsychiatric disorders using affinity scores, achieving high classification accuracy.

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

Whole-genome sequencing analysis of clozapine-induced myocarditis

The paper uses whole-genome sequencing to identify rare genetic variants associated with clozapine-induced myocarditis in 25 cases and 25 controls.

Multi-scale semi-supervised clustering of brain images: deriving disease subtypes

This paper introduces MAGIC, a multi-scale semi-supervised clustering method for brain imaging data to identify disease subtypes, and evaluates its performance on simulated and clinical datasets.

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

The paper maps individual deviations from normative brain structure in schizophrenia patients and finds high heterogeneity, with most patients showing infra-normal deviations in at least one region.

Brain-predicted age associates with psychopathology dimensions in youth

The paper examines how brain age gaps relate to psychopathology dimensions in youth, finding significant associations with psychosis, obsessive-compulsive, and general psychopathology.

Functional Connectivity of Corticostriatal Circuitry and Psychosis-Like Experiences in the General Community

The paper examines the relationship between functional connectivity of corticostriatal circuits and subclinical psychosis-like experiences in a community sample.