Melissa J. Green

Shared genetic architecture of brain age gap across 30 cohorts worldwide

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

Genetic variants for head size share genes and pathways with cancer

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

The genetic architecture of the human cerebral cortex

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

Derivation of Poly-Methylomic Profile Scores for Schizophrenia

The paper constructs a Poly-Methylomic Profile Score (PMPS) for schizophrenia using DNA methylation data and finds it is elevated in schizophrenia cases compared to controls, but not associated with bipolar disorder or symptom severity.

Pharmacological enrichment of polygenic risk for precision medicine in complex disorders

The paper develops a framework to quantify common variant enrichment in clinically actionable systems for precision medicine in schizophrenia using a pharmagenic enrichment score (PES).

Genomewide association study identifies 30 loci associated with bipolar disorder

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.