Ryota Hashimoto

Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder

The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.

Generalizability of Normative Models of Brain Morphometry Across Distinct Ethnoracial Groups

The paper develops and validates age- and sex-specific normative models of brain morphometry across diverse ethnoracial groups, showing high accuracy in multiple populations.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia

The paper identifies hypermethylation of SLC6A4 in male schizophrenia patients and links it to reduced amygdala volume and 5-HTTLPR genotype.

Polygenic architecture of human neuroanatomical diversity

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia

The paper shows that placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia, with ELCs enhancing PRS effects.

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.