Molecular BiologyBiomoleculesPeer-reviewed
Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
Perla Citlali Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson…·William R. Thompson
This study identifies a novel mechanosensory complex in osteocytes involving perlecan and α2δ1 subunit, showing that gabapentin disrupts their interaction and impairs bone mechanosensation.
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