This paper shows KMT5C-H4K20me3 affects the epigenetic landscape independently of H3K9me3, promoting activating marks and protecting genome regions from uncontrolled expression.

bioRxiv · May 14, 2026 · PreprintGenomics

Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer

Ikjot Singh Sohal, Sydney N. Shaw, Andrea P dos Santos, Bennett D. Elzey, Haley Anne Harper, Carli J. McMahan, Lauren N. Meeks, Humna Hasan, Zulaida Soto-Vargas, Noor Abdullah, Subhransu Sahoo, Majid Kazemian, Matthew Richard Olson, Andrea L. Kasinski

This study identifies TGOLN2-driven extracellular vesicles from the Golgi that suppress T cell function and are associated with poor cancer survival.

bioRxiv · May 13, 2026 · PreprintCell Biology

Enhancing microRNA activity through increased endosomal release mediated by nigericin

Esteban A. Orellana, Ahmed M. Abdelaal, Loganathan Rangasamy, Srinivasarao Tenneti, Sunghyun Myoung, Philip Stewart Low, Andrea L. Kasinski

This paper develops a method to enhance miRNA activity by promoting endosomal escape using nigericin and folate ligands, enabling cytoplasmic delivery and RNAi activation.

Molecular Therapy — Nucleic Acids · Apr 11, 2019Peer-reviewedMolecular Biology