This paper shows KMT5C-H4K20me3 affects the epigenetic landscape independently of H3K9me3, promoting activating marks and protecting genome regions from uncontrolled expression.

bioRxiv · May 14, 2026 · PreprintGenomics

The circadian gene Dec2 promotes pancreatic cancer dormancy by regulating tumor cell antigen presentation to facilitate immune evasion

Lan Wang, Chris R. Harris, Crissy Dudgeon, Orjola Prela, Juliana Cazarin, Ching-Hua Shih, Christina Davidson, Anthony Casabianca, Subhajyoti De, Wade C. Narrow, Jennifer Becker, Paul M. Grandgenett, Michael Anthony Hollingsworth, Jean L. Grem, Minsoo Kim, , Darren R. Carpizo

This study identifies Dec2 as a circadian gene that promotes pancreatic cancer dormancy by reducing MHC-I antigen presentation, enabling immune evasion.

Developmental Cell · Apr 30, 2026Peer-reviewedCancer Biology

Comparative genomics approaches accurately predict deleterious variants in plants

Thomas J. Y. Kono, Lei Li, Ching-Hua Shih, Paul Hoffman, Peter Laurent Morrell, Justin C. Fay

The paper evaluates seven comparative genomic methods for predicting deleterious variants in Arabidopsis thaliana and finds their relative performance varies across species.

G3 Genes Genomes Genetics · Oct 1, 2018Peer-reviewedBioinformatics