Author

Bofeng Liu

Center for Life SciencesORCID 0000-0002-9602-8248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Wei XieiD· 3 shared Lijia LiiD· 2 shared Anming MengiD· 1 shared Bingjie ZhangiD· 1 shared Fang-Nong LaiiD· 1 shared Feng Kong· 1 shared Feng LiuiD· 1 shared Fengling CheniD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersDevelopmental Biology

Wei XieORCID

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3 papers

Recent·Most cited

NR5A2 connects genome activation to the first lineage segregation in early mouse development

Fang-Nong Lai, Lijia Li, Xiaoyu Hu, Bofeng Liu, Ziqi Zhu, Ling Liu, Qiang Fan, Huabin Tian, Kai Xu, Xukun Lu, Qing Li, Feng Kong, Lijuan Wang, Zili Lin, Hongyu Deng, , Wei Xie

This study identifies NR5A2 as a key regulator linking zygotic genome activation to the first lineage segregation in early mouse development.

bioRxiv · Nov 25, 2022 · PreprintDevelopmental Biology

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs

Xiaotong Wu, Hongmei Zhang, Bingjie Zhang, Yu Zhang, Qiuyan Wang, Weimin Shen, Xi Wu, Lijia Li, Weikun Xia, Ryohei Nakamura, Bofeng Liu, Feng Liu, Hiroyuki Takeda, Anming Meng, Wei Xie

The paper shows that global DNA methylation inheritance and enhancer dememorization in zebrafish embryos protect embryonic gene programs by preventing ectopic gene activation.

Science Advances · Dec 22, 2021Peer-reviewedDevelopmental Biology

Evaluation of ChIC-based data requires normalization that properly retains signal-to-noise ratios

Bofeng Liu, Fengling Chen, Wei Xie

The paper highlights a normalization issue in ChIC-based methods that distorts signal-to-noise ratios, leading to misleading results in open chromatin bias analysis.

bioRxiv · Aug 14, 2021 · PreprintBioinformatics