Hiroyuki Takeda

Extraocular Photoreception Controls nocturnal hatching via a neuroendocrine pathway in False Clownfish

This study shows that extraocular photoreception controls hatching timing in false clownfish via a TRH-Ca2+-hatching enzyme neuroendocrine pathway, with sensitivity to green light.

Differential spreading behaviors of Nodal signalling molecules in the extracellular space cooperatively shape left-right asymmetry

The paper shows how Nodal and Gdf1 spread freely while Dand5 is immobilized, shaping left-right asymmetry in zebrafish embryos.

Wntless interacts with Notch signaling to balance the generation of neurons and gliocytes in vertebrate dorsal diencephalon

The paper shows that Wntless restricts Notch signaling to balance neuron and gliocyte generation in zebrafish dorsal diencephalon.

Cell cycle length regulates heterochromatin reprogramming during early development in non-mammalian vertebrates

The paper shows that cell cycle length controls H3K9me3 reprogramming in non-mammalian vertebrates by affecting DNA replication-dependent erasure and re-accumulation of the mark.

Mechanically Sensitive HSF1 is a Key Regulator of Left-Right Symmetry Breaking in Zebrafish Embryos

This study identifies HSF1 as a mechanically sensitive regulator of left-right symmetry breaking in zebrafish embryos through nodal flow-induced gene expression asymmetry.

High-fat diet in early life triggers both reversible and persistent epigenetic changes in the medaka fish (Oryzias latipes)

This study shows that early-life high-fat diet in medaka fish causes both reversible and persistent epigenetic changes in the liver, affecting metabolic genes and disease-related pathways.

Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium

The paper identifies epigenetically distinct clonal compartments in the medaka fish dorsal pallium, revealing unique open chromatin patterns and synaptic features in the Dd2 region.

Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r

The paper identifies Zic1's role in epaxial myotome morphogenesis by regulating Wnt11r to guide dorsal movement and neural tube coverage.

Histone marks retained during epigenetic reprogramming and their roles essential for fish early development

The paper identifies histone modifications retained during epigenetic reprogramming in medaka embryos and demonstrates their functional roles in development.

Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation

This study shows that KV-epithelial cells in zebrafish can transdifferentiate into mesodermal lineages after their initial role in left-right patterning.

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs

The paper shows that global DNA methylation inheritance and enhancer dememorization in zebrafish embryos protect embryonic gene programs by preventing ectopic gene activation.

A genetic model of congenital intestinal atresia in medaka (Oryzias latipes) implicates Mypt1 in epithelial organisation

This paper identifies a medaka mutant with congenital intestinal atresia, linking Mypt1 dysfunction to actomyosin dysregulation and epithelial disorganisation.

CTCF looping is established during gastrulation in medaka embryos

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.

Evolutionary transition in accessible chromatin landscapes during vertebrate embryogenesis

The paper shows that more evolutionarily derived gene regulatory regions are activated later in embryogenesis across three vertebrate species.

Measuring the Landscape of CpG Methylation of Individual Repetitive Elements

The paper develops an algorithm to measure CpG methylation in repetitive elements using SMRT sequencing, achieving high sensitivity and precision in medaka and human genomes.