Nicole A. Teran

Safety First: Input Screening for Protein Design Tools

The paper introduces a screening method for protein design tools that evaluates functional and structural features to identify potentially harmful targets, showing high accuracy and distinguishing between benign and damaging mutations.

Nonsense-mediated decay is highly stable across individuals and tissues.

The paper assesses NMD efficiency for PTVs across tissues and individuals, finding high concordance and demonstrating in silico prediction using peripheral tissues.

Identification and characterization of centromeric sequences in Xenopus laevis

This study identifies and characterizes centromeric sequences in Xenopus laevis using CENP-A ChIP-seq and k-mer analysis, revealing diverse repeat sequences and mapping centromere positions on each chromosome.

A vast resource of allelic expression data spanning human tissues

The paper presents a large ASE resource from GTEx v8 with 431 million SNP-level and 153 million haplotype-level measurements, and extends phASER to estimate cis regulatory variant effect sizes.

Determinants of telomere length across human tissues

The paper examines telomere length variation across 6,391 tissue samples from 952 individuals, showing tissue-specific differences, positive correlations between tissues, and associations with age and ancestry.

A Quantitative Proteome Map of the Human Body

The paper quantifies protein levels across 32 human tissues and compares them to transcriptome data, revealing insights into post-transcriptional regulation and disease mechanisms.

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

This study evaluates the use of whole blood transcriptome sequencing for diagnosing rare diseases, finding an 8.5% diagnostic rate across 56 undiagnosed cases.

Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

This paper introduces ChAR-seq, a method to map RNA-to-DNA contacts genome-wide, identifying chromatin-bound RNA targets such as nascent transcripts and trans-associated RNAs.