Author

LeAnn P. Nguyen

Benaroya Research InstituteORCID 0000-0002-9640-8902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

John P. RayiD· 2 shared Ailing LuiD· 1 shared Amanda HuangiD· 1 shared Arpit Mishra· 1 shared Betsy Jo BarnesiD· 1 shared Carl G. de BoeriD· 1 shared Ching‐Huang HoiD· 1 shared Florence M. ChardoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

John P. RayORCID

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2 papers

Recent·Most cited

Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation Syndrome

Natalie K. Thulin, Ailing Lu, Susana L. Orozco, Amanda Huang, LeAnn P. Nguyen, Gargi Mishra, Ram Savan, William L. Clapp, John Ray, Jessica A. Hamerman, Betsy Jo Barnes

This study identifies IRF5 as a critical driver of iHPC differentiation and MAS pathogenesis, showing it can be targeted pharmacologically.

bioRxiv · Oct 16, 2026 · PreprintImmunology

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells.

Ching‐Huang Ho, Maxwell A. Dippel, Meghan S. McQuade, LeAnn P. Nguyen, Arpit Mishra, Stephan Pribitzer, Samantha R. Hardy, Harshpreet Chandok, Florence M. Chardon, Troy A. McDiarmid, Hannah A. DeBerg, Jane Hoyt Buckner, Jay Shendure, Carl G. de Boer, Michael H. Guo, , John P. Ray

The paper identifies 545 expression-modulating variants in CD4+ T cells linked to autoimmune diseases and shows they regulate genes in a lymphocyte activation network.

Nature Genetics · Sep 18, 2025Peer-reviewedGenetics