The paper develops an ex vivo model of BPD using airway epithelial cells and identifies a molecular endotype characterized by vimentin expression and ciliary loss in infants with BPD.

American Journal of Respiratory Cell and Molecular Biology · Mar 6, 2026Peer-reviewedCell Biology

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells.

Ching‐Huang Ho, Maxwell A. Dippel, Meghan S. McQuade, LeAnn P. Nguyen, Arpit Mishra, Stephan Pribitzer, Samantha R. Hardy, Harshpreet Chandok, Florence M. Chardon, Troy A. McDiarmid, Hannah A. DeBerg, Jane Hoyt Buckner, Jay Shendure, Carl G. de Boer, Michael H. Guo, , John P. Ray

The paper identifies 545 expression-modulating variants in CD4+ T cells linked to autoimmune diseases and shows they regulate genes in a lymphocyte activation network.

Nature Genetics · Sep 18, 2025Peer-reviewedGenetics

Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis

Susan Canny, Ian B. Stanaway, Sarah E. Holton, Mallorie A. Mitchem, Allison R. O’Rourke, Stephan Pribitzer, Sarah K. Baxter, Mark M. Wurfel, Uma Malhotra, Jane Hoyt Buckner, Pavan K. Bhatraju, Eric D. Morrell, Cate Speake, Carmen R. Mikacenic, Jessica A. Hamerman

The paper identifies biomarkers and genetic variants associated with COVID-19 linked secondary hemophagocytic lymphohistiocytosis (sHLH) and links them to immune system defects.

bioRxiv · Aug 13, 2024 · PreprintImmunology