The paper compares epigenetic aging estimates between the 450K and EPICv2 arrays, finding that some clocks are affected by missing probes, but overall correlations remain strong.

Mechanisms of Ageing and Development · Dec 5, 2025Peer-reviewedGenetics

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

Albert Higgins‐Chen, Kyra Thrush, Yunzhang Wang, Christopher J. Minteer, Pei‐Lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, Ann Zenobia Moore, Stefania Bandinelli, Christiaan H. Vinkers, Eric H. G. J. M. Vermetten, Bart P. F. Rutten, Elbert Geuze, , Morgan E. Levine

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

Nature Aging · Jul 15, 2022Peer-reviewedBioinformatics

An integrative analysis of clinical and epigenetic biomarkers of mortality

Tianxiao Huan, Steve Nguyen, Elena Colicino, Carolina Ochoa‐Rosales, William David Hill, Jennifer A. Brody, Mette Soerensen, Yan Zhang, Antoine Baldassari, Mohamed A. Elhadad, Toshiko Tanaka, Yinan Zheng, Arce Domingo‐Relloso, Dong Heon Lee, Jiantao Ma, , Daniel A Levy

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

Aging Cell · May 12, 2022Peer-reviewedGenetic & Genomic Medicine

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Eleonora Porcu, Marie C. Sadler, Kaido Lepik, Chiara Auwerx, Andrew R. Wood, Antoine Weihs, Maroun S. Bou Sleiman, Diogo M. Ribeiro, Stefania Bandinelli, Toshiko Tanaka, Matthias A. Nauck, Uwe Völker, Olivier Delaneau, Andres Metspalu, Alexander Teumer, , Zoltán Kutalik

This paper introduces revTWMR, a method to determine causal relationships between gene expression and complex traits, finding that traits more strongly influence gene expression than vice versa.

Nature Communications · Sep 24, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia‐Ling Kuo, Janice L. Atkins, Joshua Richard Lewis, ThuyVy Duong, Shengjun Hong, Mary Lou Biggs, Jian’an Luan, Chloé Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, , Luke C. Pilling

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

Nature Communications · Jan 28, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

Daniel L. McCartney, Josine L. Min, Rebecca Claire Richmond, Ake Tzu-Hui Lu, Maria Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Şeyma Katrinli, Pei‐Lun Kuo, Pamela R. Matías‐García, Pashupati Prasad Mishra, , Jerome I. Rotter

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

bioRxiv · Jun 29, 2020 · PreprintGenetics

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning W. Tiemeier, Janine F. Felix, , Cornelia M. van Duijn

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Nature Communications · Jun 13, 2019Peer-reviewedGenomics

Discovering patterns of pleiotropy in genome-wide association studies

Jianan Zhana, CHARGE ECG Working Group, Jessica van Setten, Jennifer A. Brody, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola Del Greco M, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, , Steven Ron Cummings

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

bioRxiv · Feb 28, 2018 · PreprintGenetics

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, M. Fabiola Del Greco, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, Martina Müller‐Nurasyid, , Paolo Gasparini

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

bioRxiv · Jan 17, 2018 · PreprintGenetics