Therapeutic Targeting of the TGFβ Pathway Augments CAR T cell Efficacy in Glioblastoma
Darya Alizadeh, Robyn A. Wong, Madeleine S. Maker, Dominic J. Bellavari, Jonathan C. Hibbard, Heini M. Natri, Wuyang Chen, Min-Hsuan Chen, Xiwei Wu, Yate‐Ching Yuan, Joseph R. Pecoraro, John David Jeppson, Renate Starr, Zhiqiang Wang, Nicholas E. Banovich, , Christine E. Brown
This study shows that targeting the TGFβ pathway improves CAR T cell efficacy in glioblastoma by enhancing antitumor activity and modulating the tumor microenvironment.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology