Author

Min-Hsuan Chen

City Of Hope National Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Xiwei WuiD· 3 shared Stephen J. FormaniD· 2 shared Andrew Zhang· 1 shared Behnam BadieiD· 1 shared Bryan Garcia· 1 shared Byungchang JiniD· 1 shared Cassandra Nichole SprackleniD· 1 shared Charles BrenneriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Xiwei WuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Therapeutic Targeting of the TGFβ Pathway Augments CAR T cell Efficacy in Glioblastoma

Darya Alizadeh, Robyn A. Wong, Madeleine S. Maker, Dominic J. Bellavari, Jonathan C. Hibbard, Heini M. Natri, Wuyang Chen, Min-Hsuan Chen, Xiwei Wu, Yate‐Ching Yuan, Joseph R. Pecoraro, John David Jeppson, Renate Starr, Zhiqiang Wang, Nicholas E. Banovich, , Christine E. Brown

This study shows that targeting the TGFβ pathway improves CAR T cell efficacy in glioblastoma by enhancing antitumor activity and modulating the tumor microenvironment.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy

Lior Goldberg, Eric R. Haas, Jiaqi Wu, Bryan Garcia, Ryan Z. Urak, Vibhuti Vyas, Ruby Espinosa, Tamara Munoz, Shirley Bierkatz, Khyatiben V. Pathak, Nathaniel P. Hansen, Patrick Pirrotte, Jyotsana Singhal, James Lester Figarola, Ricardo Zerda Noriega, , Xiuli Wang

This study identifies immunometabolic factors in CD19 CAR T cells that predict long-term response in B-ALL patients and suggests mTOR inhibition as a strategy to enhance anti-tumor activity.

Nature Communications · Feb 20, 2026Peer-reviewedImmunology

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D. J. Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A. Herman, Cassandra Nichole Spracklen, Russell P. Goodman, Charles Brenner

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

Nature Metabolism · Nov 14, 2025Peer-reviewedMolecular Biology