Khaled Alganem

Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain

This study shows that low-dose developmental exposure to deltamethrin disrupts molecular pathways related to circadian rhythms and MAP kinase in mouse brains, linking it to ADHD-like behaviors.

Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia

The paper identifies Egr3-dependent genes in mice hippocampi after ECS, finding genes related to DNA damage response and schizophrenia.

Molecular Neurobiology of Loss

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease

The paper identifies five core protein kinases in neurons and astrocytes from familial AD patient iPSCs and examines their enriched pathways using a combination of experimental and in-silico approaches.

KRSA: Network-based Prediction of Differential Kinase Activity from Kinome Array Data

KRSA predicts differential kinase activity from kinome array data by analyzing phosphorylation differences and comparing results to gene expression databases.

Kaleidoscope: A New Bioinformatics Pipeline Web Application for In Silico Hypothesis Exploration of Omics Signatures

Kaleidoscope is a web application that provides access to omics databases and tools for in silico hypothesis exploration, demonstrating its use with DISC1 gene analysis across multiple datasets.

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

The paper identifies lamina-specific gene expression changes in pyramidal neurons from schizophrenia patients compared to controls, highlighting immune and synaptic pathway disruptions.

Integrative Omics for Informed Drug Repurposing: Targeting CNS Disorders

This paper reviews signature-based in silico approaches for drug repurposing in CNS disorders, integrating data science platforms to improve clinical relevance and address regulatory and knowledge challenges.

Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex

The paper examines protein expression levels of prenyltransferase subunits in schizophrenia patients and finds decreased expression of FNTA, PGGT1B, and RABGGTB in the dorsolateral prefrontal cortex.

Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments

The paper identifies PPAR agonists as potential treatments for schizophrenia by analyzing bioenergetic changes in the DLPFC using bioinformatics and experimental validation.