This study identifies a tumor-CAF continuum in Ewing sarcoma through single-cell RNA sequencing, revealing novel surface antigens as potential immunotherapeutic targets.

bioRxiv · Aug 4, 2026 · PreprintCancer Biology

Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma

Mohammad Alhomoud, Michelle Foley, Mayumi Sugita, Joshua Alexander Fein, Samuel Yamshon, Leandro Marcelo Martinez, Kai Rejeski, Maider Astorkia, Doron Betel, Renier J. Brentjens, Koen van Besien, Lorenzo Galluzzi, Olivier Boyer, J. Martinet, Silvia Chiara Formenti, Mónica L. Guzmán

This study shows that total body irradiation before CAR T cell infusion enhances their effectiveness against large B-cell lymphoma by improving cytotoxicity and survival outcomes.

bioRxiv · Mar 17, 2025 · PreprintCancer Biology

Endogenous CD28 drives CAR T cell responses in multiple myeloma

Mackenzie M. Lieberman, Jason H. Tong, Nkechi U. Odukwe, Colin A. Chavel, Terence J. Purdon, Rebecca Burchett, Bryan M. Gillard, Craig M. Brackett, AJ Robert McGray, Jonathan L. Bramson, Renier J. Brentjens, Kelvin P. Lee, Scott H. Olejniczak

This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.

bioRxiv · Mar 21, 2024 · PreprintCancer Biology