Author

Paulo J. da Costa

Institut de Biologie Moléculaire et CellulaireORCID 0000-0002-9749-9965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Cecília M. ArraianoiD· 1 shared Charlotte LalouxiD· 1 shared Claire RegostiD· 1 shared Coline Leghay· 1 shared David L BlumiD· 1 shared Florian Vermon· 1 shared Franck MartiniD· 1 shared Giovanni ChiappettaiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Cecília M. ArraianoORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer Disease

Sarah Guedjdal, Coline Leghay, Maxime J. Derisbourg, Sabiha Eddarkaoui, Simon Lecerf, Florian Vermon, Raphaëlle Caillierez, Séverine Bégard, Claire Regost, Charlotte Laloux, Paulo J. da Costa, Kévin Carvalho, Giovanni Chiappetta, Yann Verdier, Valérie Buée‐Scherrer, , Malika Hamdane

This study identifies and characterizes a novel N-terminally acetylated Tau variant that accumulates in AD models and patients, exacerbates pathology, and is a potential therapeutic target.

Translational Neurodegeneration · Apr 27, 2026Peer-reviewedNeuroscience

A role for DIS3L2 over human nonsense-mediated mRNA decay targets

Paulo J. da Costa, Juliane Menezes, Margarida Saramago, Juan F. García-Moreno, Hugo A. F. Santos, Margarida Gama‐Carvalho, Cecília M. Arraiano, Sandra C. Viegas, Luı́sa Romão

This study identifies DIS3L2 as a key player in human nonsense-mediated mRNA decay, showing it degrades full-length transcripts and depends on uridylation.

bioRxiv · Aug 2, 2019 · PreprintMolecular Biology