Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole M. Guerrera, Alexandria Regan, Liqin Lin, Erica L. Schwarz, A. Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam Brickman Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, , Edward P. Manning
The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.
Aging Cell · Jan 27, 2026Peer-reviewedPhysiology