Author

Nicole M. Guerrera

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Edward P. ManningiD· 4 shared Xiting YaniD· 4 shared A. JustetiD· 3 shared Abhay B. RamachandraiD· 3 shared Jack Di PaloiD· 3 shared Pramath DoddaballapuriD· 3 shared Rira ChoiiD· 3 shared Alexandria Regan· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Edward P. ManningORCID

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Author profile →

4 papers

Recent·Most cited

Crystalline silica exposure causes latent biomechanical abnormalities along the cardiopulmonary axis

Meredith S. Gwin, Jack Di Palo, Anthony A. Fung, Rira Choi, Péter Hermán, Alexandria Regan, Aishani Nagamalla, Asad A Syed, Theodore Sandow, Ying Sun, Sydney L. Bluestein, Buqu Hu, Yo Sep Shin, Keshav Harpavat, Clemente J. Britto, , Edward P. Manning

This study shows that a single crystalline silica exposure causes subclinical cardiopulmonary abnormalities in mice, with sex-dependent effects on lung mechanics and transcriptomic responses.

bioRxiv · Oct 24, 2026 · PreprintPhysiology

Biological Aging of the Cardiopulmonary System

D K Liu, Pramath Doddaballapur, Zhongyu Cai, Rira Choi, Jack Di Palo, Nicole M. Guerrera, Nebal Abu Hussein, Meredith S. Gwin, Liqin Lin, Siming Zheng, Yuening Zhang, A. Justet, Abhay B. Ramachandra, Xiting Yan, Edward P. Manning

This study quantifies biological cardiopulmonary aging in mice by integrating biomechanics and single-cell transcriptomics, revealing non-linear aging patterns and cell-type-specific gene expression changes.

bioRxiv · Jun 12, 2026 · PreprintPhysiology

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole M. Guerrera, Alexandria Regan, Liqin Lin, Erica L. Schwarz, A. Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam Brickman Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, , Edward P. Manning

The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.

Aging Cell · Jan 27, 2026Peer-reviewedPhysiology

Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise

Abhay B. Ramachandra, Prapti Sharma, Ruben De Man, Fadi Nikola, Nicole M. Guerrera, Pramath Doddaballapur, Cristina Cavinato, Rira Choi, Micha Sam Brickman Raredon, Jason M. Szafron, Zhen W. Zhuang, Thomas Bärnthaler, A. Justet, Ngozi D. Akingbesote, Nebal S. Abu Hussein, , Edward P. Manning

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

bioRxiv · Feb 15, 2025 · PreprintPhysiology