Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours
Colin D.H. Ratcliffe, Hugh Sparks, Giulia L. M. Boezio, Yuriy Alexandrov, Robert P. Jenkins, Alix Le Marois, Pablo Soro-Barrio, Fatemeh Ahdmadi Moughari, Heather Hulme, Rebecca J. Lee, Stephanie Strohbuecker, Sudeep Joshi, James K. Ellis, Giacomo Fabrini, Lucy Flint, , Erik A. Sahai
This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.
bioRxiv · Jun 6, 2025 · PreprintCancer Biology