Immune History Modifies Disease Severity to HPAI H5N1 Clade 2.3.4.4b Viral Challenge
Pamela H. Brigleb, Bridgett Sharp, Ericka Kirkpatrick Roubidoux, Victoria Meliopoulos, Shaoyuan Tan, Brandi Livingston, Dorothea R. Morris, Tyler J. Ripperger, Lauren Lazure, Velmurugan Balaraman, Alexis C. Thompson, Katie E. Kleinhenz, Kiril M. Dimitrov, Paul Glyndwr Thomas, Stacey Schultz‐Cherry
The paper shows that pre-existing immunity from H1N1 infection or vaccination can protect against lethal HPAI H5N1 clade 2.3.4.4b challenge in mice and ferrets, independent of hemagglutination inhibition titers.
bioRxiv · Oct 23, 2024 · PreprintMicrobiology