Author

Saskia Trump

Berlin Institute of Health at Charité - Universitätsmedizin BerlinORCID 0000-0002-9894-1807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:protein sequence· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Christian ConradiD· 2 shared Irina LehmanniD· 2 shared Leif Erik SanderiD· 2 shared Marcus Alexander MalliD· 2 shared Robert Lorenz ChuaiD· 2 shared Roland EilsiD· 2 shared Anke Seegebarth· 1 shared Bettina HeideckeriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Christian ConradORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Evolution of SARS-CoV-2 reshapes upper airway immunity in children

Sophie McEwen, Jobst Fridolin Roehmel, Sebastian Wisniewski, Jennifer Loske, Marey Messingschlager, Johannes Liebig, Robert Lorenz Chua, Anke Seegebarth, Foo Wei Ten, Birgit Sawitzki, Leif Erik Sander, Christian Conrad, Roland Eils, Marcus Alexander Mall, Irina Lehmann, Saskia Trump

This study uses single-cell transcriptomics to show that SARS-CoV-2 variants reshape pediatric upper-airway immunity differently from adults.

bioRxiv · Oct 16, 2026 · PreprintImmunology

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L. Heppner, Roland Eils, Marcus Alexander Mall, John Brent Richards, Leif Erik Sander, Irina Lehmann, , Claudia Langenberg

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.

Nature Communications · Aug 15, 2022Peer-reviewedGenetic & Genomic Medicine