Leif Erik Sander

Evolution of SARS-CoV-2 reshapes upper airway immunity in children

This study uses single-cell transcriptomics to show that SARS-CoV-2 variants reshape pediatric upper-airway immunity differently from adults.

Innate immune sensing of cell traversal by Plasmodium sporozoites drives protective T cell responses

The paper shows that Plasmodium sporozoites trigger innate immune responses via cell traversal, which is essential for activating protective CD8+ T cells.

Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury

This study identifies CXCL5 as a factor that increases alveolar-epithelial barrier permeability in acute lung injury, independent of neutrophil recruitment.

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19

This study links gut microbiota dysbiosis and altered tryptophan metabolism to increased inflammation in severe COVID-19 patients.

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.