Author

Irina Lehmann

German Center for Lung ResearchORCID 0000-0001-8875-5587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Roland EilsiD· 4 shared Christian ConradiD· 3 shared Jennifer LoskeiD· 3 shared Leif Erik SanderiD· 3 shared Marcus Alexander MalliD· 3 shared Robert Lorenz ChuaiD· 3 shared Birgit SawitzkiiD· 2 shared Jobst Fridolin RoehmeliD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

Roland EilsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolution of SARS-CoV-2 reshapes upper airway immunity in children

Sophie McEwen, Jobst Fridolin Roehmel, Sebastian Wisniewski, Jennifer Loske, Marey Messingschlager, Johannes Liebig, Robert Lorenz Chua, Anke Seegebarth, Foo Wei Ten, Birgit Sawitzki, Leif Erik Sander, Christian Conrad, Roland Eils, Marcus Alexander Mall, Irina Lehmann, Saskia Trump

This study uses single-cell transcriptomics to show that SARS-CoV-2 variants reshape pediatric upper-airway immunity differently from adults.

bioRxiv · Oct 16, 2026 · PreprintImmunology

Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19

Kristin Köhler, Lorna Morris, Agata Rakszewska, Robert Lorenz Chua, Maciej Balura, Katharina Jechow, Jennifer Loske, Roland Eils, Irina Lehmann, Peter N. Robinson, Christian Conrad

This study uses long-read single-cell RNA sequencing to identify cell-type specific alternative splicing changes in COVID-19 patients compared to healthy controls.

bioRxiv · Sep 23, 2025 · PreprintGenomics

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

Lev Petrov, Sophia Brumhard, Sebastian Wisniewski, Philipp Georg, David Hillus, Anna Luisa Hiller, Rosario Astaburuaga-García, Nils Blüthgen, Emanuel Wyler, Katrin Vogt, Hannah-Philine Dey, Saskia Freifrau von Stillfried, Christina Iwert, Roman David Bülow, Bruno Märkl, , Birgit Sawitzki

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

Cell Reports Medicine · Aug 1, 2025Peer-reviewedImmunology

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L. Heppner, Roland Eils, Marcus Alexander Mall, John Brent Richards, Leif Erik Sander, Irina Lehmann, , Claudia Langenberg

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.

Nature Communications · Aug 15, 2022Peer-reviewedGenetic & Genomic Medicine