Sara Kathrin Goetz

Regulated conformational transitions in seipin define a functional ER–lipid droplet interface

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

Structural reorganization underlying stress-induced cytoplasmicsolidification in yeast

The paper investigates the structural basis of stress-induced cytoplasmic solidification in yeast, finding that acidification drives supramolecular assembly rather than uniform crowding.

Convolutional networks for supervised mining of molecular patterns within cellular context

DeePiCt is a deep-learning framework for segmenting and localizing macromolecular complexes in cryo-electron tomograms, showing effectiveness in identifying low-abundance structures across species.