Florencia M. McAllister

This study identifies KRAS-driven metabolic reprogramming through MFSD2A-mediated lysophosphatidylcholine scavenging as a driver of PDAC progression and shows that targeting this pathway with edelfosine has anti-cancer effects.

This study shows aerobic exercise improves PDAC vascular function and chemotherapy efficacy via S1PR1 signaling in tumor endothelial cells.

This study shows that ketogenic and high-fat diets accelerate pancreatic cancer progression in mice, leading to more aggressive tumors and a pro-inflammatory microenvironment.

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.